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Ehlers-Danlos syndrome, Chronic Fatigue, Chronic Lyme, vascular abnormalities, Fibromyalgia, and Multiple Sclerosis. Dr. Diana is now Migraine headaches affect more than 30 million Americans and can be more than just a nuisance. For many, migraines are a disabling neurological disorder that can be highly disruptive to a normal lifestyle, forcing people to miss work school, social events, and sometimes forcing them into dark, quiet rooms for hours, if not days. To date, treatment for migraine headaches involved their prevention (avoiding some common food triggers or stress, for example), and treatment with painkillers, botox, and anti-inflammatory medications. For many, these treatments have been insufficient, and patients’ lifestyles have continued to suffer dramatically. I am happy to tell you that two new medications have been recently approved for migraines that attack these vascular headaches from a much more focused direction. Rather than provide patients with less generalized painkilling or anti-inflammatory medications, these new drugs act on “CGRP”, that is “calcitonin gene-related peptide” (or the receptors). This clas* of medications falls under the “monoclonal antibody therapies” -- a different approach from current therapies. Calcitonin gene-related peptide is a protein that is released around the brain. When CGRP is released, it causes intense inflammation in the coverings of the brain (the meninges). For most migraine patients, CGRP causes the pain of a migraine attack. In fact, if you give CGRP intravenously to a person prone to developing migraines, most of them will get a migraine within four hours. That’s the basis of all the Once it was determined that CGRP caused a migraine, it became clear that if we could do something to stop CGRP, we could probably stop a migraine. Four companies decided to create antibodies against CGRP and against the receptor to which CGRP binds. AimovigTM (erenumab) is a monoclonal antibody against the CGRP receptor. The additional new medications are monoclonal antibodies